Research Research Research Programs Systems, Pathways & Targets Biotechnology, Imaging & Drug Development Cancer Control Clinical Research Disease-Oriented Teams Stern Center for Cancer Clinical Trials and Research Research Resources Shared Resources Funding Opportunities Membership Guidelines Acknowledgement of Shared Resources Centers & Institutes Anti-Cancer Challenge Research Anti-Cancer Challenge RFP Team Funds Anti-Cancer Challenge Past Awardees Disease-Oriented Teams Home Research Clinical Research Disease Oriented Teams A Disease-Oriented Team (DOT) is a multidisciplinary group of basic, translational, clinical and population researchers who collaborate around a specific anatomic cancer area to further the translation of Cancer Center discoveries (e.g. new targets, biomarkers, drugs, biological agents, diagnostic and therapeutic devices) through the pipeline towards interventional clinical trials. What Does a DOT Do? Through their collective expertise, DOTs steward the Cancer Center's clinical research efforts, managing the clinical trials portfolio around the following principles: scientific merit, soundness of trial design, accrual potential, and likelihood for correlative translational science. Facilitate the translation of scientific discoveries to address specific types of cancer Promote multidisciplinary collaboration to address disease-specific questions Determine interest in and commitment to a trial and the potential to accrue Ensure adequate internal review of scientific quality and feasibility of clinical trials, and oversees prioritization of protocols Review clinical research portfolio and develops and brings forward new trials, including investigator-initiated trials Catalyze new multi-investigator, multidisciplinary preclinical and clinical translational research Submit a Protocol for Review All cancer-related hypothesis-drive clinical research studies must undergo a feasibility review by the corresponding DOT or Tumor Board. To submit a study for review, download and complete the application. Download Application Disease-Oriented Teams and Leadership Roster DOT Leader Breast Oncology Ritesh Parajuli, MD Devon Lawson, PhD Erin Lin, DO Gastrointestinal Oncology Jason Zell, DO Mehraneh Dorna Jafari, MD Genitourinary Oncology Edward Uchio, MD Michael McClelland, PhD Gynecologic Oncology Fabio Cappuccini, MD Lydia Su, PhD Hematologic Malignancies Angela Fleischman, MD, PhD Deepa Jeyakumar, MD Neuro-Oncology Daniela Bota, MD, PhD Frank Hsu, MD Skin Cancer Kenneth Linden, MD, PhD Bogi Andersen, MD Tumor Boards At UCI, our tumor boards are a group of doctors and other health care providers with different specialties that meet regularly to discuss cancer cases and share knowledge. The board’s goal is to determine the best possible cancer treatment and care plan for an individual patient. Tumor Board Frequency Contact Neuro Oncology Weekly Naudia Chappell, email@example.com Breast UCIMC/Pacific Breast Weekly Naudia Chappell, firstname.lastname@example.org Gastrointestinal Weekly Naudia Chappell, email@example.com Genitourinary Bi-weekly Naudia Chappell, firstname.lastname@example.org Gynecologic Oncology Weekly Leticia Vazquez, email@example.com Head & Neck Weekly Andrea Desanto, firstname.lastname@example.org Hepatobiliary Weekly William To, email@example.com Lung Bi-weekly Naudia Chappell, firstname.lastname@example.org Malignant Hematology Bi-weekly Naudia Chappell, email@example.com Pigmented Lesion Monthly Naudia Chappell, firstname.lastname@example.org Sarcoma Bi-weekly Naudia Chappell, email@example.com Join a DOT Please contact us at CancerCenter_Committees1@hs.uci.edu to learn more.