Core Connection
  May 1, - July 31, 2013


www.cancer.uci.edu/shared_resources.asp
 In This Issue 


Shared Resources
  Biobehavioral
  Biostatistics
  Experimental Tissue Resource
  Genomics High-Throughput
  In-Vivo Onco-Imaging
  Optical Biology Core
  Transgenic Mouse Facility 
  
Other Items
  Contact Us
  Did You Know?
  Don't Forget
  Funding Opportunities
  Social Networking Tools
  You Are Invited...

Research Programs
Our research efforts are organized into four research programs, which serve to foster interactions and collaborations within specific themes. Cancer center members are affiliated with one program but work with collaborators from different programs in multi-disciplinary groups.

The Chao Family Comprehensive Cancer Center's four research programs are:

Cancer Prevention & Prognosis (CPP)
Chemical & Structural Biology (CSB)
Onco-Imaging & Biotechnology (OIB)
Systems, Pathways & Targets (SPT)
Associate Members (AS)

  Don't Forget

Employee Bulletin
Federal Funding that maintains support for cancer center cores (and keeping prices low) depends critically on papers published that use our center facilities. As NIH transitions to digital, it becomes critically important that you list the support of the cancer center support grant in all appropriate publications. Verification of acknowledgment of support will come from electronically scanned publications and cannot be altered after publication. It is essential that you CITE THE CANCER CENTER SUPPORT GRANT (CCSG) if your publication is cancer-related and supported by the center, such as: "Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number P30CA062203. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.”

 Countdown to the
 Progress Report

Calendar


days until the cancer center's progress report is due, November 27, 2013.
 Did You Know?  

?
Three of our shared resource facilities (ETR, IVFOI and OBC), plus resources offered by the Laboratory for Fluorescence Dynamics (LFD), may be of particular interest to investigators wishing to perform image analysis of vertebrate animal models (or cells derived thereof) that have abnormal development or homeostasis, including cancer.

Learn More

 You Are Invited...  

Invitation

Oseroff Photomedicine Lecture
Oct. 10, 3:30 p.m.
Calit2 Auditorium, UC Irvine campus

Society for Adolescent and Young Adult Oncology - "AYA Cancer Rights"
Oct. 16-17
Beckman Center of the National Academies of Sciences and Engineering, Irvine

Women’s DOT Meeting

Oct. 18, 11:30 a.m.
UC Irvine Medical Center
Building 55, Room 212

Colon DOT Meeting
Oct. 22, 5 p.m.
UC Irvine Medical Center
Building 3, Room 101

Chao Lectureship (Public)
Oct. 22
5 p.m. Reception
6 p.m. Lecture
Beckman Center, UC Irvine campus
"Understanding Performance: Can Exercise Mimetics Replace Exercise?"

Chao Lectureship (Scientific)
Oct. 23, Noon
Tamkin Lecture Hall (F-110)
UC Irvine campus
"Nuclear Receptors and the Hunger Games: From Feast to Famine"

Skin DOT Meeting
Oct. 28, 6 p.m.
UC Irvine Medical Center
Building 22A, Room 2103/2104

Prostate DOT Meeting
Oct. 30, 3 p.m.
UC Irvine Medical Center
Douglas Hospital, Room 4843

Women’s DOT Meeting
Nov. 15, 11:30 a.m.
UC Irvine Medical Center
Douglas Hospital, Room 4843

16th Annual Scientific Retreat
Nov. 15-16
Hyatt Regency Suites
Palm Springs, CA

Skin DOT Meeting
Nov. 25, 1 p.m.
UC Irvine campus
BLI Library

Shared Resources Directors Meeting
Closed Meeting
Nov. 26, 3 p.m.
UC Irvine Campus
Sprague Hall 105

Colon DOT Meeting
Nov. 26, 5 p.m.
UC Irvine Medical Center
Building 22A, Room 2103/2104

Prostate DOT Meeting
Nov. 27, 3 p.m.
UC Irvine Medical Center
Douglas Hospital, Room 4843

 Funding Opportunities  


$

Internal Funding Opportunities

Please contact:
Jacqueline Tidball
Associate Director, CCSG Administration
tidball@uci.edu

External Funding Opportunities


The cancer center’s extramural awards analyst provides services that include identifying federal and private funding opportunities and discovering project-specific funding sources, in addition to timely editorial and proposal writing support.

Please contact:
Alisz Demecs
Extramural Awards Analyst
ademecs@uci.edu

 Social Networking Tools  

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 Contact Us  

Email
The Chao Family Comprehensive Cancer Center supports seven shared resources that provide services essential to basic and translational research. Each of these is available to researchers at UC Irvine and other institutions. Investigators do not have to be cancer center members to use the facilities. Each shared resource is partially funded by user fees and other support. To learn more about the services offered and how they might benefit your research, please refer to the specific contact information listed under the shared resource section of this newsletter or contact:

Jacqueline Tidball
Associate Director, CCSG Administration
tidball@uci.edu

Jennifer Ivask
Community Engagement Manager
jivask@uci.edu



 Biobehavioral Shared Resource Facility (BBSR)

Wenzel Director: Lari Wenzel, PhD
Phone:
949-824-3926
Manager:
Susie Hsieh, PhD
Phone:
949-824-3384

Location:
UC Irvine, 212 Sprague Hall, Irvine, CA 92697
www.cancer.uci.edu/resources/biobehavioral.asp

The goal of the Biobehavioral Shared Resource Facility (BBSR) is to support cancer researchers by providing them with the necessary expertise and assistance to incorporate patient/participant-reported outcomes (PROs), health-related quality-of-life (QOL) and counseling interventions within clinical trials into their research. The BBSR participates in translational research in psychoneuroimmunology, examination of behavioral issues that enhance recruitment and compliance within cancer center clinical trials and development of behavioral and QOL outcomes associated with clinical trials. The primary activities of the BBSR include: consultation on behavioral and/or QOL self-report measurement, research design, data collection, interpretation of self-report data, manuscript preparation and counseling interventions within clinical trials..

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Quarterly Highlights
The Biobehavioral Shared Resource Facility (BBSR) continues to assist Dr. Jason Zell’s (CPP) “Phase 2A Clinical Biomarker Trial of Aspirin and Arginine Restriction in Colorectal Cancer Patients” trial. The BBSR worked with Dr. Zell to develop a psychosocial telephone counseling intervention for an integrative oncology project that examines the effects of oral aspirin taken daily with an arginine-restricted diet on certain colorectal cancer biomarkers in treated colorectal cancer patients. The director and co-director of the BBSR, as well as a clinical psychologist, devoted time and expertise to this study and used patient reported outcomes to assess the effectiveness of patient telephone counseling (PTC) for the intervention arm of this clinical trial.



 Biostatistics Shared Resource Facility (BSR)

Gillen Director: Daniel L. Gillen, PhD
Phone: 949-824-9862
Facility Manager: Michael J. Phelan, PhD
Phone: 949-824-9637

Location:
101 The City Drive South, Bldg. 56, Rm. 228, Orange, CA 92868

www.cancer.uci.edu/biostatistics/index.asp

The mission of the Biostatistics Shared Resource (BSR) faculty and staff is to support the conception, design, implementation, analysis and reporting of research conducted by members of the Chao Family Comprehensive Cancer Center.

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Quarterly Highlights
A considerable change in the Biostatistics Shared Resource Facility (BSR) has transpired - the Standard Operation Procedures for Services and Fees has been updated. The BSR effort for assistance with grant preparation for cancer-related studies will now be free-of-charge to cancer center members and their co-investigators. In an attempt to better serve cancer center members, the effort for assistance with grant preparation for cancer-related studies is now free-of-charge to funded cancer center members and their co-investigators.



 Experimental Tissue
 Shared Resource Facility (ETR)

EdwardsDirector: Robert Edwards, MD, PhD
Phone: 949-824-8576
Facility Manager: Kehui Wang
Phone: 949-824-8974

Location: UC Irvine, Medical Science Building I, D-440, Irvine, CA 92697
www.cancer.uci.edu/resources/experimental_tissue.asp


The primary objective of the Experimental Tissue Shared Resource (ETR) is to provide basic, translational and clinical cancer center researchers access to, and analysis of, human and animal tissues.

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Quarterly Highlights


Histology services were again the most frequently used component of the Experimental Tissue Shared Resource Facility (ETR) this past quarter, with 23 cancer center users, including 18 full members with peer-reviewed funding. Of the remaining five member users without peer reviewed funding, one was a full member and four were associates. The leading users of the histology service usage this quarter were Dr. Ulrike Luderer (CPP) and Dr. Hirohito Ichii (AS).

Learn More

 Genomics High-Throughput Facility (GHTF) 

Sandmeyer Director: Suzanne Sandmeyer, PhD
Phone: 949-824-7571
Facility Manager: Melanie Oakes, PhD
Phone: 949-824-6023
Bioinformatics Director: Chad Garner, PhD
Phone: 949-824-2036

Location: UC Irvine, 340 Sprague Hall, Irvine CA 92697
www.cancer.uci.edu/resources/genomic.asp

The mission of the UC Irvine Genomics High-Throughput Facility (GHTF) is to provide genome-wide analysis for clients interested in gene expression, regulation of gene expression and genome sequence and variation. The primary forms of genome-wide analysis are the Affymetrix GeneChip, Illumina HiSeq 2500 next-generation sequencing and PacBio RS real-time single molecule sequencing.

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Quarterly Highlights
Our next-generation sequencing (NGS) technologies include the Illumina HiSeq 2500 with dual mode capabilities; therefore, the Genomics High-Throughput Facility (GHTF) can now sequence samples in rapid run or high output modes which will allow faster turnaround times. The core continues its work with the Hyundai Cancer Institute to develop a model for studying the genomics of pediatric cancers that can eventually be implemented for adult cancers within the Chao Family Comprehensive Cancer Center. The pediatric cancer cases recruited are being utilized to develop the automated clinical genomics pipeline that will be available for future cancer genome projects at the cancer center.

Learn More

 In-Vivo Functional Onco-Imaging (IVFOI) 

GulsenDirector: Gultekin Gulsen, PhD
Phone:
949-824-6001
Facility Manager:
TBD
Phone:
949-824-6001

Location:
UC Irvine, 164 Irvine Hall, Irvine, CA 92697
www.cancer.uci.edu/resources/in_vivo.asp


The long-term goal of the In-Vivo Functional Onco-Imaging (IVFOI) core is to promote the application of imaging techniques in cancer research. Toward this aim, the development and application of imaging technologies are key research areas. The current imaging facilities at the center include: a 15-cm bore 7-Tesla MR system (small animals) a 94-cm bore 4-Tesla MR system (human/small animals), a 57-cm bore 3-Tesla MR system (humans), a combine MR-Diffuse Optical Tomography (MR-DOT) system (small animals), and a whole-body positron emission tomography (PET) system (humans). All combined multimodality systems were developed in-house.

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Quarterly Highlights

In-Vivo Functional Onco-Imaging (IVFOI) spent considerable time preparing a cutting-edge imaging system for Dr. Leslie Randall's (SPT) upcoming preclinical study. Several years ago IVFOI built the world's first MR compatible Single Photon Emission Tomography (SPECT) system for small animal imaging. With the preliminary data that the core was able to collect using this first prototype, Dr. Randall secured funding for the validation of Bevacizumab as a potential VGEF marker in ovarian cancer because of the preliminary data that this core captured using this first prototype.

PI: Leslie Randall, MD
Funding Agency: The American Board of Obstetrics and Gynecology
Title: “Preclinical Validation of 123I-Bevacizumab as a Potential Pharmacodynamic Marker of Vascular Endothelial Growth Factor Activity and Predictive Marker of Bevacizumab Response”
Total funding: $450,000

This success story shows the value of the IVFOI: cutting-edge multimodality imaging provided to cancer center researchers to help them secure extramural funding for their novel research.


Learn More

 Optical Biology Core (OBC) 

Marsh Director: J. Lawrence Marsh, PhD
Phone:
949-824-6677
Facility Manager:
Adeela Syed
Phone:
949-824-3226
Location:
UC Irvine, 5302 Biological Sciences II, Irvine, CA 92697
www.cancer.uci.edu/resources/optical_biology_core.asp

The mission of the Optical Biology Core (OBC) is to provide researchers access to resources, including state of the art instrumentation and technical support, to conduct biomedical research.

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Quarterly Highlights

The Optical Biology Core will offer “refresher” training that will give cancer center members an opportunity to check if their imaging parameters are ideal for the best quality image. They will also have a Fluorescence Lifetime-resolved Imaging (FLIM) and Fluctuation Correlation Spectroscopy (FCS) workshop, taught by Michelle Digman, PhD, who will educate members on the benefits and uses of the newly installed FLIM box. For Fluorescence Activated Cell Sorting (FACS), the facility has a dual laser DAKO Cytomation MoFlo® Flow Cytometer that is capable of simultaneous high-speed sorting of two independent populations based on any of eight parameters. Other activities include further development and expanding capabilities of Laser Microbeam and Medical Program (LAMMP) instrumentation.

Learn More

 Transgenic Mouse Facility (TMF) 

RandallDirector: Grant MacGregor, PhD
Phone:
949-824-8253
Facility Manager:
Tom Fielder
Phone:
949-824-6496

Location:
UC Irvine, Biological Sciences III, Rm. B138, Irvine, CA 92697
www.cancer.uci.edu/resources/transgenic_mouse_facility.asp

The Transgenic Mouse Facility (TMF) assists in the use of genetically modi­fied mice in biological and biomedical research. An important goal of the TMF is to identify new technology and methodology that is likely to benefit UC Irvine investigators using mice in their research programs and to import and provide such technology to UC Irvine investigators. The TMF makes investigators aware of new and existing developments via the TMF website, in seminars and lectures, via the UC Irvine MouseUsers email list and by word of mouth.

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Quarterly Highlights

To improve BioSecurity, the Transgenic Mouse Facility (TMF) will relocate the TMF managing director's office, stem cell culture suite and sperm cryopreservation facility to the second floor of BioSci3 to improve BioSecurity. The core recently completed beta testing of a new method of performing DNA microinjections for Nanoinjection Technologies. The core evaluated the potency of an in-house developed ES cell line (SWD5) that can be used to introduce genetic modifications to reduce the time required for principal investigators to generate conditional mutant alleles of mice.

Learn More