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Project Title

Investigator

Program Area

Phase II trial of sequential systemic therapy plus intraperitoneal paclitaxel in gastric/GEJ cancer peritoneal carcinomatosis

Senthil, Maheswari

Biotechnology, Imaging & Drug Development

Radiogenomics-guided personalized treatment for hormonal receptor positive metastatic breast cancer and post-neoadjuvant chemotherapy residual disease

Su, Lydia

Biotechnology, Imaging & Drug Development

Personalized therapeutic cancer vaccines to effectively mobilize anti-tumor T cell immunity in non-small cell lung cancer

Hughes, Christopher

Biotechnology, Imaging & Drug Development

Pathophysiological role of complement C1q in glioma

Acharya, Munjal

Biotechnology, Imaging & Drug Development

Real-time dosimetric measurements for FLASH radiotherapy with acoutstic emission

Xiang, Liangzhong

Biotechnology, Imaging & Drug Development

Targeted therapy in addition to salvage chemotherapy for patients with primary refractory AML as a bridge to allogeneic stell cell transplantation

Jeyakumar, Deepa

Systems, Pathways & Targets

Characterizing the bioenergetic shift in triple negative breast cancer metastasis

Lawson, Devon

Systems, Pathways & Targets

Assessment of clonal hematopoiesis as a predisposing factor for severe COVID-10 infection

Fleischman, Angela

Systems, Pathways & Targets

Active in vivo metabolites of p53 reactivation small molecules

Jang, Cholsoon

Systems, Pathways & Targets

The role of alternative pre-mRNA processing in colon cancer

Hertel, Klemens

Systems, Pathways & Targets

Use of levocarnitine for asparaginase hepatotoxicity for acute lymphoblastic leukemia patients

Huynh, Van

Systems, Pathways & Targets

Mechanisms of local Treg expansion in melanoma following PD-1 blockade

Marangoni, Francesco

Systems, Pathways & Targets

Human lymphoma organoids as a screening platform for drug discovery and precision medicine in Non-Hodgkin lymphoma

Wagar, Lisa

Systems, Pathways & Targets

A pilot study of immunotherapy combined with stereotactic ablative radiotherapy for patients with advanced or metastatic sarcoma

Harris, Jeremy

Cancer Control

SHORT: UCI 20-09: SHOrt Course Radiation and TASOX (TAS102 plus Oxaliplatin) Chemotherapy in Operable Rectal Cancer, a Phase II Trial

Zell, Jason

Cancer Control

Overcoming barriers to health-information seeking behavior and potential for technology for childhood cancer survivors (CCS)

Hayes, Gillian

Cancer Control

Project Title

Investigator

Program Area

Pilot study for evaluating the multiphoton microscopy potential for non-invasive, early diagnosis of melanoma

Kelly, Kristen

Biotechnology, Imaging & Drug Development

Developing the Next Generation Antibody Drug Conjugates

Weiss, Gregory

Biotechnology, Imaging & Drug Development

Melanoma Screening and Staging with a Fiber Optical Device

Hedde, Per Niklas

Biotechnology, Imaging & Drug Development

Novel Inhibitors of phosphoinositide 3-kinase (PI3K) that target scaffold protein-mediated interactions

Bardwell, Lee

Systems, Pathways & Targets

Restoring p53 activity in human cancer

Qiao, Feng

Systems, Pathways & Targets

Dissecting MAP4K kinases in cancer development and therapy

Wang, Wenqi

Systems, Pathways & Targets

Phase 2 Study of cabozantinib combined with ipilimumab/nivolumab and transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC) who are not candidates for curative intent treatment

Dayyani, Farshid

Systems, Pathways & Targets

A Randomized Clinical Trial to Assess the Impact of a Remotely Administered Mediterranean Diet Intervention on Symptom Burden and Inflammatory Cytokines in Myeloproliferative Neoplasm

Fleischman, Angela

Systems, Pathways & Targets

Clock-dependent inflammatory and metabolic alterations in colorectal cancer

Masri, Selma

Systems, Pathways & Targets

Neoadjuvant combination therapy with Cabozantinib and Nivolumab in patients with muscle-invasive urothelial carcinoma of the bladder who are Cisplatin-eligible and are candidates for radical cystectomy

Mar, Nataliya

Systems, Pathways & Targets

Feasibility of a Biobehavioral Intervention to Reduce Adverse Outcomes in Young Adult Hispanic Men with Testicular Cancer

Hoyt, Michael

Cancer Control

The burgeoning cannabis industry and availability of cheap tobacco in Orange County, CA

Timberlake, David

Cancer Control

Pilot study of the safety and feasibility of immediate postoperative chemotherapy in patients with metastatic invasive colonic adenocarcinoma

Jafari, Mehraneh Dorna

Cancer Control

Factors Associated with Helicobacter Pylori Screening and Treatment among High-Risk Asians in Orange County: Mixed-Methods Research to Examine Stomach Cancer Disparity

Lee, Sunmin

Cancer Control

Goal Directed Intervention for Adolescent Cancer Survivors

Fortier, Michelle

Cancer Control

Project Title

Investigator

Program Area

Macropinocytosis drives anabolism and drug resistance in breast cancer

Edinger, Aimee

Biotechnology, Imaging & Drug Development

Single-cell transcriptome analysis of human Merkel Cell Carcinoma heterogeneity by single-cell RNA sequencing

Gao, Ling

Biotechnology, Imaging & Drug Development

True multi-modal image-guided intervention system

Nouizi, Farouk

Biotechnology, Imaging & Drug Development

Advancing Oro-Pharyngeal Cancer Screening and Diagnosis to Overcome Disparities and Improve Control and Outcomes

Wilder-Smith, Petra

Biotechnology, Imaging & Drug Development

Experimental Therapeutics for Primary Pediatric Brain Tumors

Plant, Ashley

Biotechnology, Imaging & Drug Development

Role of Phosphatase Methylation in One-Carbon Metabolism and Cancer

Kaiser, Peter

Systems, Pathways & Targets

A Phase 1b study of TAS102 in combination with irinotecan in patients with advanced gastric and gastroesophageal adenocarcinoma

Dayyani, Farshid

Systems, Pathways & Targets

A phase I study of pitavastatin in combination with venetoclax for chronic lymphocytic leukemia (CLL) or acute myeloid leukemia (AML)

Brem, Elizabeth

Systems, Pathways & Targets

UHRF1 as a therapeutic target for osteosarcoma

Benavente, Claudia

Systems, Pathways & Targets

Molecular mechanism of APOBEC3B-Mediated Mutation Shower in Ovarian Cancer

Buisson, Remi

Systems, Pathways & Targets

Control of B cell survival & transformation by the eIF4F translation initiation complex

Fruman, David

Systems, Pathways & Targets

Improving Depression Screening in a Multi-ethnic Cancer Population

Wenzel, Lari

Cancer Control

DNA methylation markers for exposures to BPA and related compounds and breast cancer risk

Park, Hannah Lui

Cancer Control

The relationship between the gut microbiome and the efficacy of immune checkpoint inhibitors in patients with gynecologic malignancy

Tewari, Krishnansu

Cancer Control

A mechanistic study of age-dependent gender difference in melanoma risk

Liu-Smith, Feng

Cancer Control

Development and Testing of a Mobile Application for Young Adults with Cancer

Hoyt, Michael

Cancer Control

Project Title

Investigator

Program Area

RhoJ Inhibitors- A Novel Treatment for Early Stage Melanoma

Ganesan, Anand

Biotechnology, Imaging & Drug Development

Pilot study of mirtazapine for the dual treatment of depression and temozolomide-induced nausea and vomiting (CINV) in newly-diagnosed glioma patients

Bota, Daniela

Biotechnology, Imaging & Drug Development

Identifying the anti-neoplastic targets of SH-BC-893

Edinger, Aimee

Biotechnology, Imaging & Drug Development

Immunotherapeutic’s targeting altered N-glycosylation in cancer

Demetriou, Michael

Biotechnology, Imaging & Drug Development

Glutamine supplementation deters melanoma tumor growth via epigenetic reprogramming

Kong, Mei

Systems, Pathways & Targets

Repurposing statins to enhance efficacy of BH3 mimetics in multiple myeloma

Fruman, David

Systems, Pathways & Targets

Circadian Metabolic Deregulation of Colorectal Cancer

Masri, Selma

Systems, Pathways & Targets

Feasibility Study of a Mediterranean Diet Intervention to Reduce Inflammatory Cytokines in Patients with Myeloproliferative Neoplasms

Fleischman, Angela

Systems, Pathways & Targets

Pilot Study of the Safety and Feasibility of Immediate Adjuvant Chemotherapy in Patients with Invasive Colonic Adenocarcinoma

Pigazzi, Alessio

Systems, Pathways & Targets

Analysis of Hippo signaling in breast cancer development

Wang, Wenqi

Systems, Pathways & Targets

Modulation of the Immune Response Against Metastatic Melanoma Using CD47 Blocking Antibodies

Boiko, Alexander

Systems, Pathways & Targets

Feasibility of a Family Focused Intergenerational Social Media Intervention for Orange County Vietnamese Families to Increase Preventive Cancer Screenings

Hopfer, Suellen

Cancer Control